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The stem cells will also make it easier for conservation scientists to study the Asian elephant’s unique biology. An Asian elephant stem cell line stained in different colors to highlight different elements. Courtesy ColossalEngineering a woolly mammoth hybridThe elephant stem cells also hold the key to the mammoth’s rebirth. The research team at Colossal has already analyzed the genomes of 53 woolly mammoths from ancient DNA recovered from fossils. The number of modifications needed to make an Asian elephant resistant to the cold would be broadly similar, he said.
Persons: George Church, Ben Lamm, Eriona, Eriona Hysolli, John Davidson “, , Hysolli, Oliver Ryder, Ryder, ” Ryder, Christopher P, Michel “, Ben’s, Lamm, , That’s, We’ve, tramping, Colossal Organizations: CNN, Harvard University, Church, Dallas, Biosciences, Colossal, San Diego Zoo Wildlife Alliance, Colossal Biosciences, Christopher Locations: Dallas, , Siberia
Read previewThe startup that wants to bring the woolly mammoth back from the dead said it is inching closer to its goal after a breakthrough in creating reprogrammed elephant stem cells. These include bringing back the woolly mammoth and the dodo. But elephant stem cells remained remarkably resistant to the process, per the statement. AdvertisementAfter tweaking the chemical composition of the mixture, Colossal Scientists say they've finally cracked it. Understanding how to turn tweak these elephant stem cells into cells from the extinct species will be another hurdle to tackle going forward.
Persons: , Ben Lamm, Lamm, George Church, we've, Evan Appleton, Vincent Lynch, Lynch, Hysoli Organizations: Service, Colossal Biosciences, Business, Harvard, University at Buffalo, Science Locations: New York
CNN —An audacious collaboration between geneticists and conservationists plans to bring back the extinct dodo and reintroduce it to its once-native habitat in Mauritius. But according to the partners, its return to Mauritius could benefit the dodo’s immediate environment and other species. The Nicobar pigeon, native to the coastal regions from the Andaman and Nicobar Islands, is the closest living relative to the dodo. Then it will edit the PGCs of a Nicobar so it expresses the physical traits of a dodo. “I have studied the dodo for many years, and there is still a lot to learn about this enigmatic bird,” he added.
Persons: dodo, Beth Shapiro, , Matt James, James, Holger Hollemann, Tatayah, ” Tatayah, , dodos, Ben Birchall, Julian Hume, ” Hume, Ben Lamm, “ We’re Organizations: CNN, Colossal Biosciences, Mauritian Wildlife Foundation, Getty, Gorges, Colossal, , White Rhino, Biosciences Locations: Mauritius, Rodrigues Island, Asia, Nicobar, Park, “ Mauritius, Aigrettes, Ile
The startup has entered a collaboration with Elephant Havens, a wildlife foundation based in the Okavango Delta that cares for orphaned elephants. The findings, the organizations hope, could provide a blueprint for releasing the elephants into the wild and mammoth hybrids to the tundra. A new system for elephant monitoringHuman-wildlife conflict is the leading cause of elephant orphans in Botswana, says Elephant Havens founder Debra Stevens. After five years in the enclosure, Elephant Havens will reintroduce these bonded herds into the wild, and monitor their progress for a decade. Biotech company Colossal wants to create a hybrid combining mammoth DNA with that of Asian elephants.
Persons: , , Elephant, We’ll, , Matt James, Debra Stevens, “ That’s, Stevens, revel, Havens, Steve Metzler, Dr, Wendy Kiso, James, Debra, ” James, Ben Lamm, ” Lamm, Lamm Organizations: CNN, Colossal Biosciences, Biotech company Colossal, Colossal Locations: Botswana, Africa, rewilding, America
From Alpacas to Yaks, Mammal DNA Yields Its Secrets
  + stars: | 2023-04-27 | by ( Emily Anthes | ) www.nytimes.com   time to read: +1 min
A team of Zoonomia researchers has now used a small piece of that taxidermied tissue to learn more about the celebrity sled dog and his canine contemporaries. What can we say about his genome?”Balto, they found, was genetically “healthier” than modern purebred dogs, with more inherited genetic variation and fewer potentially harmful mutations. That finding likely stems from the fact that sled dogs are typically bred for physical performance and may be a mixture of breeds. Balto also had an assortment of genetic variants that were not present in wolves and were rare or missing in modern purebred dogs, the researchers found. Many variants were in genes involved in tissue development and may have affected a variety of traits important for sled dogs, such as skin thickness and joint formation.
Balto: A good dog with great genes
  + stars: | 2023-04-27 | by ( Will Dunham | ) www.reuters.com   time to read: +4 min
Cleveland Museum of Natural History/Handout via REUTERS. Balto was feted as a hero, the subject of books and movies, and the dog's taxidermy mount still stands on display at the Cleveland Museum of Natural History. Balto, belonging to a population of working sled dogs in Alaska, also was found to have possessed greater genetic diversity and genetic health than modern canine breeds. Balto was found to share ancestry with modern Siberian huskies and Alaskan sled dogs as well as Greenland sled dogs, Vietnamese village dogs and Tibetan mastiffs, with no discernible wolf ancestry. Balto had a body built for strength and not speed, disappointing the breeder, who had the dog neutered.
Cleveland Museum of Natural History/Handout via REUTERS. Balto was feted as a hero, the subject of books and movies, and the dog's taxidermy mount still stands on display at the Cleveland Museum of Natural History. Balto, belonging to a population of working sled dogs in Alaska, also was found to have possessed greater genetic diversity and genetic health than modern canine breeds. Sled dogs were the only viable option. Balto was found to share ancestry with modern Siberian huskies and Alaskan sled dogs as well as Greenland sled dogs, Vietnamese village dogs and Tibetan mastiffs, with no discernible wolf ancestry.
Colossal Biosciences, a biotech company, says it will aim to revive the dodo using gene editing. This is the latest attempt to revive extinct animals in the face of the biodiversity crisis. The bird is the latest in the collection of long-gone animals scientists at the company want to revive. The startup has previously said it plan to recreate the Tasmanian wolf and the woolly mammoth. A stuffed dodo bird at the Natural History Museum on February 5, 2013, in London, England.
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